tonic seizure

Methods Sixty seven cases of primary generalized tonic clonic seizure with single PHT therapy were investigated. Adjustment of PHT dose depended on clinical effects and drug concentrations in serum and the efficacy was observed for more than half an year.

方法选择苯妥英钠单药治疗的原发性全身强直一阵挛性发作（PGTCS）患者67例，根据临床效果，结合实测血药浓度，调整剂量，至少观察半年判断临床疗效。

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Results The onset age of the patient was 7 years old. The seizure was characterized clinically by absences accompanied by severe bilateral rhythmical myoclonias, often associated with a tonic contraction.

结果患者起病年龄为7岁，发作表现为失神伴严重的双侧节律性阵挛，常有强直性收缩。

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Conclusion: Intractable occipital epileptic patients always had abnormal MRI image, general tonic clonic seizure with unilateral severity sign, more vision auras and good surgical outcome.

结论：顽固性非肿瘤枕叶癫痫患者的特点多有结构异常，以单侧为主的强直-痉挛性癫痫多见，幻视先兆常见，手术效果好。

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Possible risk factors include: tonic-clonic seizures, multiple antiepileptic drugs therapy and poor seizure control.

强直-阵挛性发作、联合用药及癫痫控制不良是SUDEP的危险因素。

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